Biomarker development for intervention studies in aging | Postgraduate study (2023)

Table of Contents
Qualification(s) available: PhD Biomarker development for intervention studies in aging Project details Supervisors Entry requirements Entry requirements for United Kingdom Afghanistan Albania Algeria Argentina Armenia Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bolivia Bosnia and Herzegovina Botswana Brazil Brunei Bulgaria Cambodia Cameroon Canada Chile China Universities given special consideration Colombia Costa Rica Croatia Cuba Cyprus Czech Republic Denmark Dominican Republic Ecuador Egypt El Salvador Estonia Ethiopia Finland France Georgia Germany Ghana Greece Grenada Guatemala Guyana Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Israel Italy Ivory Coast Jamaica Japan Jordan Kazakhstan Kenya Kosovo Kuwait Latvia Lebanon Liberia Libya Lithuania Macau Macedonia Malawi Malaysia Malta Mauritius Mexico Moldova Mongolia Morocco Mozambique Myanmar (Burma) Namibia Nepal Netherlands New Zealand Nicaragua Nigeria Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Poland Portugal Qatar Romania Russia Rwanda Saudi Arabia Senegal Serbia Sierra Leone Singapore Slovakia Slovenia South Africa South Korea Spain Sri Lanka Sudan Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand Trinidad and Tobago Tunisia Turkey Turkmenistan Uganda Ukraine United Arab Emirates United States of America Uruguay Uzbekistan Venezuela Vietnam Zambia Zimbabwe English language requirements Fees and funding Tuition fees for 2022/23 entry UK fee International fee How to apply Contact us FAQs Videos

Qualification(s) available: PhD

Entry requirements
2:1+

UK fee:
£4,596

International fee:
£25,100

Full-time
3 years

Part-time
6 years

Start date
July 2023, October 2023

Application deadline
31 July 2023

Project reference
UF-AS-2022
Location
Loughborough
Subject area(s)
Mechanical, Electrical and Manufacturing Engineering
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Project details

Human longevity has increased through improved nutrition, sanitation and healthcare in the last century. Research for extending the human lifespan has recently sped up and the first drug candidates have entered clinical trials. Biomarkers are highly valuable tools in assessing the efficacy of such interventions. Methylation clocks recently developed using methlyomic data have shown how useful bioinformatic approaches are to developing aging biomarkers. This project seeks to develop biomarkers that can help us to evaluate aging intervention approaches with a focus on the ability to quantify senescent cells.

The project will mix theoretical and experimental work. The experimental work will investigate the elimination of senescent cells and the restoration of stem cells in vitro and in vivo.

Ideally, the candidate will possess strong biomedical data processing skills. The candidate will design experiments, test hypotheses, develop and implement machine learning methods on multi-parametric data, including imaging, genomics, proteomics and metabolomics, for the development of biomarkers of aging and to assess longevity intervention approaches.

The School of Mechanical, Electrical and Manufacturing Engineering has seen 100% of its research impact rated as 'world-leading' or 'internationally excellent' (REF, 2021).

Supervisors

Primary supervisor:Professor Alexandra StolzingSecondary supervisor:Dr Tao Sun

(Video) Biomarkers of Aging

Entry requirements

Our entry requirements are listed using standard UK undergraduate degree classifications i.e. first-class honours, upper second-class honours and lower second-class honours. To learn the equivalent for your country, please choose it from the drop-down below.

Entry requirements for United Kingdom

A bachelor's degree in a scientific or engineering discipline and three years of experience or an equivalent combination of education and experience required. Completed coursework in bioinformatics, biology, computer science, and statistics. A master's degree is preferred.

  • Experience in scientific computing
  • Perl/Python scripting, visualization and statistical analysis packages
  • Experience working with omics data sets preferred
  • Experience creating and using advanced machine learning algorithms and statistics

Afghanistan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Masters 95% 85% 70%

Albania

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diplomë e Nivelit të Pare (First Level (University) Diploma (from 2010) 9.5 8.5 8

Algeria

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licence (4 year) / Diplome d'Inginieur d'Etat / Diplôme d'Etudes Supérieures 16 14 12

Argentina

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Argentina 8.5 7.5 6.0

Armenia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bakalavri Kochum 90% 80% 70%
Magistrosi Kochum 3.9 3.5 3.0

Australia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Honours degree (AQF level 8) First Class, 80% Upper Second, 70%, H2A Lower Second, 60%, 2B
Ordinary degree - AQF Level 7 pass (mark 46 or 50) High Distinction (80% or 85%) Distinction (75% or 80%) Distinction (70% or 75%)

Austria

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree/ Diplomstudium / Magister degree A (or 1.5) mit Auszeichnungbestanden 60% or B or 3.0 (or 2) 50% or C or 2.7 (or 3)

Azerbaijan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bakalavr Diplomu 4.5 4 3.5
Diplomu (Specialist Diploma) 90% 80% 70%

Bahamas

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree from University of the West Indies only 1st (GPA 3.6) 2:1 (GPA 3.0) 2:2 (GPA 2.5)

Bahrain

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.8

Bangladesh

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
BUET or 'Good Private' University - 4 year degree BUET - 1st (70%) / 3.5 BUET - 2nd (60%) / 3.0 BUET - 2nd (55%) / 2.75
Other universities - Masters (1-2 years) following a 3 or 4 year degree 80% / 4.0 65% / 3.25 50% / 2.5

Barbados

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Barbados - Degree from University of the West Indies only 1st (GPA 3.6) 2:1 (GPA 3.0) 2:2 (GPA 2.5)

Belarus

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Specialist Diploma (5Yr) 9 7 5

Belgium

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bachelor degree Magna Cum Laude Cum Laude 60%/12
Licenciaat 80% 70% 60%
Licencie 17 14 12

Belize

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree from University of the West Indies only 1st (GPA 3.6) 2:1 (GPA 3.0) 2:2 (GPA 2.5)

Benin

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Maitrise 18 15 or Bien 12 or Assez Bien

Bermuda

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree from University of the West Indies only 1st (GPA 3.6) 2:1 (GPA 3.0) 2:2 (GPA 2.5)

Bolivia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
A Licenciado, 4 years Private (public/private) 85/78 75/66 67/55

Bosnia and Herzegovina

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diploma Visokog Obrazovanja / Diplomirani 10 9 8

Botswana

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's degree A or 80% B or 70% C or 60%

Brazil

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Brazil - 4 yr Bacharel or Licenciado/Licenciatura or Título Profissional 8.5 7.5 6.5

Brunei

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Brunei First Upper Second (60%/B/3.1) Lower Second (50%/C/2.7)

Bulgaria

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
5 yr Diploma za Zavarsheno Visshe Obrazovanie (Diploma of Completed Higher Education) 6 5 4

Cambodia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 years 90% or 9 or 4.0 80% or 8 or 3.5 70% or 7 or 3.0

Cameroon

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bachelor degree or Diplome d'Etudes Superiures de Commerce 1st or 15 2:1 or 14 2:2 or 12.5
Diplome d'Ingenieur or Diplôme d'Ingénieur de Conception or a Maitrise or a 4 year Licence 20 or GPA 3.7 20 or Bien (GPA 3.4) 20 or Assez Bien (GPA 3.1)

Canada

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0/percentage scale 3.7/85% 3.3/75% 2.7/68%
Out of 9 8 6 5
Out of 12 10 8 6

Chile

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Grado de Licenciado / Título (Profesional) de [subject area] (4 years) 6 5.5 5

China

Students are required to have a bachelor degree (4 years) for entry to a postgraduate programme. The University uses the Shanghai Academic Ranking of World Universities to identify the required final mark, as outlined on the table below:

First class (70%) Mid 2:1 (65%) 2:1 (60%) Mid 2:2 (55%) 2:2 (50%)
Shanghai Rank Top 250 83% 79% 75% 73% 70%
Shanghai Rank 251-500 88% 84% 80% 78% 75%
Shanghai Rank 501+ 92% 87% 84% 82% 80%

The University will consider students from Affiliated Colleges in the following way:

Applicants from colleges affiliated to universities in the top 250 Shanghai rankings will be considered if they have achieved or are likely to achieve final marks of 75%-84%.

Applicants from colleges affiliated to universities which are 251-500 in the Shanghai rankings will be considered if they have achieved or are likely to achieve final marks of 80%-87%.

Applicants from colleges affiliated to universities which are above 500 in the Shanghai rankings will be considered as follows:

  • School of Business and Economics: not considered
  • All other programmes if they have achieved or are likely to achieve final marks of 80%-87%.

Universities given special consideration

Applicants from a small number of Chinese universities that specialise in business, management, finance or creative arts will be given special consideration by the University. The full list of these universities and the Shanghai band under which they will be considered can be found below:

UniversityChinese nameConsidered inband
Beijing Film Academy北京电影学院Top 250
Capital University of Physical Education and Sports*首都体育学院Top 250
Central Academy of Drama中央戏剧学院Top 250
Central Academy for Fine Arts中央美术学院Top 250
Central Conservatory of Music中央音乐学院Top 250
China Academy of Art中国美术学院Top 250
Guangxi University of Finance and Economics广西财经学院251-500
Harbin University of Finance (Harbin Finance University)哈尔滨金融学院251-500
Northwest University of Political Science and Law上海海关学院Top 250
Shanghai Customs College上海海关学院Top 250
Shanghai Theatre Academy上海戏剧学院)Top 250
Tianjin Sport University*天津体育学院Top 250

‌*Special consideration for programmes in School of Sport, Exercise and Health Sciences and Institute for Sport Business only.

(Video) Aging biomarkers and geroprotective interventions Dr. Chistine Yuan Huang

Students who do not meet the above requirements may occasionally be considered if they have a relevant degree, can show good grades in relevant subjects, and/or have substantial relevant work experience.

Colombia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciado / Título de [subject area] 4.5 3.75 3.2

Costa Rica

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciado 9 8 or 80 7 or 75

Croatia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Baccalaureus / Prvostupnik 4.5 3.8 3.0

Cuba

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4-year Titulo de Licenciado / Licenciatura 5 4 3

Cyprus

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Cyprus 8.5 7.0 6.5

Czech Republic

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bakalár (after 2001)6 yr integrated Magistr 1 1.5 2

Denmark

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
5 year Candidatus/Candidata Magisterii or Bachelor degree (7 point scale) 12 10 7

Dominican Republic

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 year Licenciado 3.8 Magna Cum Laude 3.5 Cum Laude 3.2
Título de [subject area] - 85% 82%

Ecuador

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Título de Licenciado 8.5 8 7
Título de [subject area] 85% 80% 70%

Egypt

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Egypt 3.5 3.2 2.8
Universities only BA 90%, BSc 85% BA 80%, BSc 75% BA 65%, BSc 65%

El Salvador

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
5 year Licenciado 8.5 7.5 6.5
Título de Ingeniero 85% 75% 65%
Arquitecto - Muy Bueno Bueno

Estonia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bakalaureusekraad or Magister or Magistrikraad 5 or A 4 or B 3 or C

Ethiopia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's A/GPA 4.0 A/GPA 3.5 B/GPA 2.8

Finland

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Kandidaattii/Kandidat (out of 3) 3 2 1
Maisteri/Magister (out of 5) 4.5 3 2.5

France

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licence (3 years)/ Maitrise/ Diplôme d'Ingénieur 14 13 11

Georgia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4-year degree (% = new system) 5 (95%) 4.5 (85%) 4 (75%)

Germany

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
German Bachelor/ Diplom, Magister Artium / Zeugnis über den Zweiten Abschnitt der Ärztlichen Prüfung 1.5 2.5 3.0

Ghana

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Ghana First Upper second/60% Lower second/50%

Greece

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Universities 8.5 7.0 6
TEI and non-University Institutions 8.5 7 6.5

Grenada

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree from University of West Indies - classification 1st 2:1 2:2
Degree from University of West Indies - grade / percentage A B / 75% C / 55%
Degree from University of West Indies - GPA 3.6 3.0 2.0

Guatemala

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Liceniado / Titulo de (subject area) - 4years 90% (public university) / 95% (private university) 80% (public university) / 85% (private university) 60% (public university) / 70% (private university)

Guyana

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's GPA 4 GPA 3.5 3.0

Honduras

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Título de Licenciado / Grado Académico de Licenciatura (4 year degree) - GPA out of 5 GPA 5 or 90% GPA 4 or 80% GPA 3.5 or 70%

Hong Kong

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.5

Hungary

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Alapfokozt or Egyetemi Oklevel / Bachelor 5 4 3

Iceland

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Baccalaurreatus degree or Kandidatsprof/Candidatus Mag 8.5 7.5 6.5

India

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Institutions listed on the Indian Ranking of Higher Educational Institutions Framework
65% (First) 60% (First) 55% (Upper second)
All other Indian institutions 70% (First with distinction) 65% (First) 60% (First)

Indonesia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Sarjana I (S1) from A (or B) credited Universities 3.7 (4.0) 3.3 (3.7) 3 (3.3)

Iran

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Iran 17 15 13

Iraq

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Iraq 80% 75% 70%

Ireland

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Republic of Ireland First (70%) Upper second (60%) Lower second (50%)

Israel

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
3 yr Bachelor Degree 90% 80% 70%

Italy

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diploma di Laurea 109/110 104/110 (or 27) 100/110 (or 26)

Ivory Coast

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diplome d'Etude Approfondies, Diplome d'EtudeSuperieures or Diplome d'Etude Superieures 16 14 (Bien) 12 (Assez Bien)

Jamaica

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
For degrees studied at The University of WestIndies or degrees accredited by UCJ and CCCJ 1st (GPA 3.6) 2:1 (GPA 3.0) or B 2:2 (GPA 2.0) or C

Japan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Japan 85% 80% or B or 3.0 70% or C or 2.0

Jordan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3 or 3.5/5 or 75% 2.8 or 65%

Kazakhstan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 5.0/percentage scale 4.5 or 90% 4 or 85% 3.5 or 80%
GPA 4.33 scale 3.9 3.7 3.2
GPA 4.0 scale 3.7 3.4 3

Kenya

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Kenya First / 70% / A Upper second / 60% / B Lower second / 50% / C

Kosovo

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Kosovo 10 9 8

Kuwait

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.6 3.0 2.8

Latvia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Latvia 9 7 6
(Video) Biomarker Standardization: Quantifying Aging | Morgan Levine, Yale, Jamie Justice, Wake Forest

Lebanon

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
American 90% (3.5) 80% (3.2) 70% (2.8)
French 18 15 12

Liberia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's 4.0 or 90% 3.5 or 85% 3 or 80%

Libya

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
BSc Engineering, Architecture, Medicine 85 (3.6) 75 (3.0) 65 (2.5)
Other bachelor's degree from a university 90 (4.0) 85% (3.6) 75% (3.0)

Lithuania

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Lithuania 9 8 7

Macau

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Macau 1st or GPA 3.7 2:1 or GPA 3.0 2:2 or GPA 2.5

Macedonia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Macedonia 10 9 8

Malawi

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's only MSc 75% MSc 70% MSc 65%

Malaysia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Classification First Class 2.1 2.2
GPA 4.0 scale 3.5 3.0 2.8

Malta

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Malta 1st (80%) 2:1 (70%) 2:2 (55%)

Mauritius

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Mauritius 1st or 70% 2:1 or 60% 2:2 or 50%

Mexico

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Mexico 9 8 7

Moldova

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diploma de Licenţă (Diploma of Licentiate) 10 9 8

Mongolia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Диплом Специалиста (Specialist Diploma) 90% or 3.5 80% or GPA 3.2 70% or GPA 3.0

Morocco

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Morocco 17 15 13

Mozambique

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 year Licenciatura 16 14 12

Myanmar (Burma)

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
2 year Master's degree 5 or 85% 5 or 75% 4.5 or 65%

Namibia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Namibia 80% or A 70% or B 60% or C

Nepal

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's (after 3 year bachelor degree) 90% or 3.9 GPA 80% or 3.8 GPA 65% or 3.3 GPA

Netherlands

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Netherlands 8 7 6

New Zealand

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Year Honours degree (480 credits) - Level 8 First (7.0) Upper Second (6.0) Lower Second (4.0)
3 Year degree (360 credits) - Level 7 A+ (9.0) A- (7.0) B+ (6.0)

Nicaragua

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciatura (4 year) 90% 80% 70%

Nigeria

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
7 point Scale 6 5 4
5 point scale 4.5 3.8 3.5
4 point scale 3.5 3 2.5

Norway

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Norway A B C

Oman

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.5

Pakistan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Year degree only (the higher of the 2 option) A- or GPA 3.7 B or GPA 3.0 C+ or GPA 2.6
2 or 3 year bachelor's plus Master's First (60%) Second (55%) Second (50%)

Palestine

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bachelor Degree A / 90% / 3.7 B+ / 85% / 3.3 B / 80% / 3.0

Panama

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Year Licenciado / Título de [subject area] 91 (A) 81 (B) 71 (C)

Papua New Guinea

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Papua New Guinea 1st 2:1 2:2

Paraguay

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Year Título de Licenciado / Título de [subject area] 4.5 (85%) 4 (80%) 3.5 (75%)

Peru

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Year Título de Licenciado / Título de [subject area] 14 13 12

Philippines

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Degree from prestigious state universities or Centres of Excellence (COE) Summa Cum Laude 4.0 / 96% / 1.0 Magna cum Laude 3.5 / 92% / 1.5 Cum Laude 3.0 / 87%/ 2.0

Poland

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bachelor Degree (post 2003) Magister (pre- 2003) 5 4.5 / 4+ 4

Portugal

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Portugal 18 16 14

Qatar

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.8

Romania

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diploma de Licenta/ Diploma de Inginer 9 8 7

Russia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Russia 4.5 4.0 3.5

Rwanda

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 year bachelor (Hons) degree (480 credits) 1st, 16/20 (80%) 2:1,14/20 (70%) 2:2, 12/20 (60%)

Saudi Arabia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.8
GPA 5.0 scale 4.5 3.75 3.5

Senegal

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Maitrise, Diplome d'Etude Approfondies,Diplome d'Etude Superieures or Diplome d'Etude Superieures Specialisees 16/20 or Tres Bien 14/20 or Bien 12/20 or Assez Bien

Serbia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Diplomirani/ Bachelor's degree 9 8 7

Sierra Leone

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Honours degree or masters 1st (70%) 2:1 (60% or B) 2:2 (50% or C)

Singapore

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Classification First Upper second Lower second
GPA 4.0 scale 3.7 3.0 2.7
GPA 5.0 scale 4.5 3.5 3.0

Slovakia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Slovakia 1.5 or B 2.0 or C 2.5 or C/high D

Slovenia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Slovenia 9.5 8.5 7

South Africa

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Classification 1st 2:1 2:2
Percentage scale 75-100% 70-74% 60-69%

South Korea

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA out of 4.5 4.0 / A 3.5 / B 3.0 / C+
GPA out of 4.3 4.0 / A 3.0 / B 2.7 / C+

Spain

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciado / Título de Ingeniero / Título de Arquitecto 8.5 7 6.5
UCM grading 3.0 2.0 1.5

Sri Lanka

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 year Professional degree or Bachelor Special or Honours degree 90%, GPA 3.70 80%, GPA 3.30 70%, GPA 3.0
(Video) Role of Biological Clocks and Other Biomarkers of Aging in Regulatory Development

Sudan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Sudan (North and South) 1st or 70% or B+ 2:1 or 66% Mid 2:2 or 60% or B

Sweden

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Sweden - Overall grade of VG with a minimum of 90 credits at VG Overall grade of G with a minimum of 90 credits at G

Switzerland

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Switzerland 6 5 4

Syria

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
State universities 4 years of study 80% 70% 60%
Private universities 4 years of study 90% 80% 70%

Taiwan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Category 1 (4 year degree) 80% 75% 70%
Category 2 (4 year degree) 85% 80% 75%

Tajikistan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Tajikistan - 4.5 4

Tanzania

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Tanzania 1st 2:1 2:2

Thailand

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.8

Trinidad and Tobago

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
For degrees studied at The University of West Indies or degrees accredited by ACTT 1st or B+ or 70% 2:1 or B or 65% 2:2 or B- or 60%

Tunisia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licence, Maîtrise, Diplôme National d'Ingénieu 16 (tres bien) 14 (bien) 11 (assez bien)

Turkey

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Lisans Diplomasi or a Műhendis Diplomasi 3.5 3 2.5

Turkmenistan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
4 Yr Bakalavr, Specialist Diploma or Magistr 5 4.5 4

Uganda

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Uganda 1st or 4.4 2:1 or 3.8 2:2 or 3.0

Ukraine

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Dyplom Magistra or a Bachelors degree (11 / 5) 4.5 4.0 3.5

United Arab Emirates

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.0 2.6

United States of America

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
GPA 4.0 scale 3.5 3.2 2.8

Uruguay

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciado (4 year) 10 9 8

Uzbekistan

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Bakalavr Diplomi / Diplomi (Specialist Diploma) 90% or GPA 4.5 80% or GPA 4.0 70% or GPA 3.0

Venezuela

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Licenciado/Professional title. (4 year) 18/20 or 8/9 16/20 or 7/9 14/20 or 6/9

Vietnam

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
10-point scale 8.0 7.0 6.0
4-point scale 3.5 3.0 2.8

Zambia

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
Master's A or 4.0 or 80% B+, 3.5 or 70% B or 3.0 or 60%

Zimbabwe

First-class honours (70%) Upper second-class honours (60%) Lower second-class honours (50%)
3/4 year degree 1st or 75% 2:1 or 65% 2:2 or 60%

English language requirements

Applicants must meet the minimum English language requirements. Further details are available on the International website.

Fees and funding

Tuition fees for 2022/23 entry

UK fee

£4,596 Full-time degree per annum

International fee

£25,100 Full-time degree per annum

Find out more about research degree funding

Tuition fees cover the cost of your teaching, assessment and operating University facilities such as the library, IT equipment and other support services. University fees and charges can be paid in advance and there are several methods of payment, including online payments and payment by instalment. Fees are reviewed annually and are likely to increase to take into account inflationary pressures.

How to apply

All applications should be madeonline. Under programme name, select ‘Mechanical and Manufacturing Engineering’. Please quote reference number: UF-AS-2022.

Apply now

Contact us

  • Call us +44 (0)1509 227577
  • Email us A.Stolzing@lboro.ac.uk
  • Web chats
  • Register for email updates
(Video) Extending healthspan: AKG, human clinical trials & aging biomarkers (Prof Brian Kennedy)

FAQs

What are the stages of biomarker development? ›

In overview, the steps of biomarker development include: biomarker discovery, assay development and validation, clinical utility validation and clinical implementation [4].

What are the techniques for biomarker discovery? ›

There are three main steps in proteomic analysis in order to identify a biomarker in a specific disease. These steps including; (1) extraction and separation of proteins, (2) identification of proteins, and (3) verification of proteins (Fig. 1) (Liu et al, 2014).

How are biomarkers created? ›

Many biomarkers come from simple measurements made during a routine doctor visit, like blood pressure or body weight. Other biomarkers are based on laboratory tests of blood, urine, or tissues. Some capture changes at the molecular and cellular level by looking at genes or proteins.

What is the meaning of biomarker discovery? ›

Biomarker discovery is a medical term describing the process by which biomarkers are discovered. Many commonly used blood tests in medicine are biomarkers.

What are the 5 biomarkers of aging? ›

These include IGF-1 (insulin-like growth factor 1), insulin, glucose, C-reactive protein (a measure of systemic inflammation), triglycerides, and blood pressure.

What are the 4 types of biomarkers? ›

Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers.

What are the three types of biomarkers? ›

Diagnostic biomarkers accurately determine whether a patient has a particular disease. Genetics, proteins, and blood are the most common subgenres for diagnostic biomarkers.

What is the process of biomarker immunoassay development? ›

The process involves four continuous stages including method development, exploratory method validation, “full” or extensive method validation, and in-study method validation, and the rigorous level is driven by the intended use of the assay (Table 1).

What are the phases of biomarker validation? ›

  • Phase 1: Preclinical exploratory studies.
  • Phase 2: Clinical Assay Development for Clinical Disease.
  • Phase 3: Retrospective Longitudinal Study.
  • Phase 4: Prospective Screening Studies.
  • Phase 5: Cancer Control Studies (RCT)

What are the two main types of biomarkers? ›

Prognostic versus predictive biomarkers

Prognostic biomarkers are associated with differential disease outcomes, but predictive biomarkers discriminate those who will respond or not respond to therapy.

What factors affect biomarkers? ›

Some biomarkers were affected by strong genetic factors, whereas others mainly by environmental or clinical factors. These variables are not always independent, such as blood pressure and use of medication, which are both related to age.

What is the main purpose of biomarkers? ›

Biomarkers have many useful applications in health care, including disease prevention and detection, determination of individual disease risk, and disease monitoring. They can also be used to measure the safety or toxicity of a therapeutic regimen or certain environmental exposures.

What is biomarker testing for age? ›

At what age do you actually live? The AgeMeter® calculates functional age by noninvasively testing the body's physiological biomarkers. The AgeMeter is a valuable tool for individuals researchers, and universities interested in warding off the effects of aging.

What is an example of biomarker evidence? ›

Examples of biomarkers include everything from pulse and blood pressure through basic chemistries to more complex laboratory tests of blood and other tissues.

What are the possible problems in biomarker discovery? ›

One of the main challenges in biomarker discovery is the high number of false discoveries. This occurs when initial scientific findings associated with a new biomarker cannot be reproduced by other laboratories or independent samples.

What are key biomarkers for aging? ›

The main mechanisms identified as potential biomarkers of aging are DNA methylation, loss of histones, and histone modification. The uses for biomarkers of aging are ubiquitous and identifying a physical parameter of biological aging would allow humans to determine our true age, mortality, and morbidity.

What are the 9 biomarkers of aging? ›

The scheme enumerates the nine hallmarks described in this review: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

What are the most important biomarkers for longevity? ›

10 Important Biomarkers to Optimize Your Health
  1. Vitamin D. Optimal Range = 50-100 ng/dl. ...
  2. CRP (C-REACTIVE PROTEIN) Optimal Range < 0.5 mg/L. ...
  3. Hemoglobin A1C. Optimal Range = 4.6% – 5.5% ...
  4. Insulin. Optimal Range = 2 – 5 uIU/ml. ...
  5. RBC Magnesium. Optimal Range = 6 – 6.5 mg/dl. ...
  6. Testosterone. ...
  7. Triglyceride / HDL Ratio. ...
  8. Lipid Panel.
Aug 3, 2021

What are the most common biomarkers? ›

Cardiac Biomarkers (Blood)
  • Cardiac troponin. This protein is by far the most commonly used biomarker. It has the highest known sensitivity. ...
  • Creatinine kinase (CK). This enzyme can also be measured several times over a 24-hour period. ...
  • CK-MB. This is a subtype of CK. ...
  • Myoglobin. This is a small protein that stores oxygen.

What are the 10 established biomarkers? ›

Biomarkers
  • 1) Muscle Mass.
  • 2) Strength.
  • 3) Basal Metabolic Rate.
  • 4) Body Fat Percentage.
  • 5) Aerobic Capacity.
  • 6) Blood-sugar Tolerance.
  • 7) Cholesterol/HDL Ratio.
  • 8) Blood Pressure.

What is the perfect biomarker? ›

THE IDEAL BIOMARKER

It should be sensitive, but it should also correlate with the severity of damage. It should be accessible in the peripheral tissue; in the case of the kidney, for example, it should be measurable in either the blood or the urine.

What is another word for biomarker? ›

A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

What are key biomarkers? ›

Biomarkers are molecules that indicate normal or abnormal process taking place in your body and may be a sign of an underlying condition or disease. Various types of molecules, such as DNA (genes), proteins or hormones, can serve as biomarkers, since they all indicate something about your health.

How do I start my first biomarker? ›

Find the First Biomarker

The biomarker is located at Saint Joseph Hospital in a safe. To get to the room, you'll have to run around the building until you come across a ladder. Use the chipped wall next to it to climb up and jump onto the ladder. Now run into the office where the safe is located.

What is the 14 day rule for biomarker testing? ›

The Centers for Medicare & Medicaid Services (CMS) 14-day rule affects diagnostic tests ordered less than 14 days after an inpatient or outpatient discharge. The rule requires laboratories to bill the hospital for tests performed for Medicare patients within this 14-day window.

What is Phase 5 of biomarker evaluation? ›

The phased process has been widely accepted by the biomarker research community. The multi-step approach includes: Phase 1 – Discovery; Phase 2 – Clinical Assay and Validation; Phase 3 – Retrospective Longitudinal; Phase 4 – Prospective Screening; and Phase 5 – Cancer Control.

Why are biomarkers important in clinical trials? ›

In clinical trials, biomarkers serve a range of practical uses: Screening of patients for eligibility. Stratification into subgroups. Monitoring of responses.

What is the difference between a marker and a biomarker? ›

In molecular terms biomarker is "the subset of markers that might be discovered using genomics, proteomics technologies or imaging technologies. Biomarkers play major roles in medicinal biology. Biomarkers help in early diagnosis, disease prevention, drug target identification, drug response etc.

Why do biomarkers fail? ›

When conducting an experiment to identify biomarkers, it is crucial to design the experiment properly. 80-90% of all biomarker populations for the last 20 years have not and cannot be reproduced, and the main reason that biomarkers fail is that these experiments are not designed properly.

What are the benefits of biomarkers of aging? ›

Individuals could use a biomarker of aging to track their biological age over time, measure the effect of diet, exercise, and drugs and predict their effects to extend lifespan or improve quality of life. Medicines could be designed and identified based on their effect on biological age.

How do biomarkers work? ›

Biomarker testing helps characterize alterations in the tumor. Biomarkers can be DNA, RNA, protein or metabolomic profiles that are specific to the tumor. Testing can include genomic testing to look at the DNA sequence, DNA or RNA tests to look for gene fusions, or tests to measure RNA or protein levels.

How long does biomarker testing take? ›

Q: How long does it take to get biomarker testing results back? Liquid biopsy results take about 5-7 days. Tissue biopsy results take about 2-4 weeks (depending on if it is done in house or needs to be sent out).

What questions to ask about biomarker testing? ›

3 After testing, ask these questions: “Did you test me for these biomarkers?” “What are the results of these tests?” “Can I get a copy of my test results?” If the test results are negative, ask “Should I be retested?”

Are biomarkers always accurate? ›

Errors are most often made when biomarker data are over interpreted. For example, the results of one study may indicate that a specific biomarker (collected as a measure of an exposure or susceptibility) is strongly associated with a particular disease or outcome.

What is biomarker assay development? ›

Assay development refers to the efforts to develop and optimize a testing system (assay) for quantifying biomarkers. Assay qualification refers to the efforts to evaluate and characterize how well this assay performs as an analytical method.

What is the regulatory pathway for biomarkers? ›

Regulatory pathways for the integration of biomarkers in drug development. The US Food and Drug Administration (FDA) outlines three primary sources for biomarker evidence, which include scientific community consensus, drug-specific development and approval process, and the biomarker qualification program (Figure 2).

What is 14 3 3 biomarker? ›

14-3-3η has been reported to be a novel RA-related biomarker inducing the expression of multiple factors mediating the pathogenesis of RA, and increasing the diagnostic capture when combined with rheumatoid factor and anticyclic citrullinated peptide antibody.

What does biomarker level 2 mean? ›

New Level 2: Cancer Mutations with Evidence of Clinical Significance Tests for biomarkers described as cancer mutations with evidence of clinical significance enable health care professionals to use information about their patients' tumors in accordance with the clinical evidence, such as clinical evidence presented in ...

What is the criteria for a good biomarker? ›

THE IDEAL BIOMARKER

It should be sensitive, but it should also correlate with the severity of damage. It should be accessible in the peripheral tissue; in the case of the kidney, for example, it should be measurable in either the blood or the urine.

What are guideline recommended biomarkers? ›

These eight guideline-recommended biomarkers include EGFR mutations, ALK fusions, ROS1 fusions, BRAF V600E mutation, RET fusions, MET amplification and MET exon 14 skipping variants, and ERBB2 (HER2) mutations. Clinical practice guidelines continue to expand with the most recent version of the NCCN guidelines (v03.

What is the turnaround time for biomarker testing? ›

Median turnaround times from biomarker testing orders to results ranged from 10 to 15 days for the individual biomarkers and 18 days for NGS.

What are examples of biomarkers? ›

Examples of biomarkers include everything from pulse and blood pressure through basic chemistries to more complex laboratory tests of blood and other tissues.

What is the difference between marker and biomarker? ›

In molecular terms biomarker is "the subset of markers that might be discovered using genomics, proteomics technologies or imaging technologies. Biomarkers play major roles in medicinal biology. Biomarkers help in early diagnosis, disease prevention, drug target identification, drug response etc.

Videos

1. Biomarkers of aging and epigenetic clocks | Peter Attia, M.D. & Matt Kaeberlein, Ph.D.
(Peter Attia MD)
2. Biomarker & Aging Clock Development | Vadim Gladyshev, Harvard, Gordan Lauc, GlycanAge
(Foresight Institute)
3. Top biomarkers for measuring aging | Eric Verdin
(FoundMyFitness Clips)
4. The Social Environment and Biomarkers of Aging Study (SEBAS)
(ICPSR)
5. 171- Longevity science: caloric restriction studies, aging biomarkers & possible longevity molecules
(Peter Attia MD)
6. Polina Mamoshina - Deep Biomarkers of human aging
(ARDD)
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